Abstract
Background: oligometastatic breast cancer patients achieved better progression-free survival without significant toxicity, so this urge patients subgroups identification who might gain more benefit from aggressive local therapy. In comparison to antro posterior, post anterior, and direct post anterior techniques, 3-dimensional conformal irradiation delivered for treatment of lumbar vertebrae metastasis was much better in the decrease of bowel and spinal cord exposure. Aim of the work: to evaluate clinical outcome gains achieved by 3D radiotherapy versus 2D radiotherapy in certain breast cancer patients with bony oligo metastasis with expected favorable survival.Methods: In a retrospective cohort, 60 patients were enrolled in 2D versus 3D arm. Treatment and survival outcomes were observed. Results: 3D radiotherapy offer a significantly better pain response, local control, and lower toxicity than patients were received treatment delivery by 2D radiotherapy with p-value = 0.004,0.002 and 0.004 respectively, patients were delivered 2D radiotherapy had shown a progressive disease than those treated by 3D radiotherapy of statistical significance p-value = 0.01. The 3D arm was better than the 2D arm in the term of better significant PFS and nonsignificant OS, p-value = 0.04, 0.14 respectively. Conclusion:3D conformal radiotherapy is of great value in the improvement of local control, pain response, progression-free survival, and overall survival with a tolerable toxicity profile in breast cancer patients diagnosed with bony oligo metastasis.
Keywords; Conformal radiotherapy, 2-dimensional radiotherapy, oligometastatic, breast cancer