Background: In childhood immune thrombocytopenia (ITP), anti-platelet autoantibodies mediate platelet clearance through Fc-γ receptor (FcγR)–bearing phagocytes. The current study aimed to assess the frequency of FcγRIIa Gene Polymorphism in Egyptian children with chronic ITP and its relation to the disease process and chronicity compared to controls.
Methods: the current case control retrospective study was conducted in Hematology unit of pediatric department, Zagazig University children Hospital, on 40 chronic ITP pediatric patients and 40 matched age and sex healthy controls, during a period from January 2018 until January 2019.All patients were subjected to detailed full history taking, complete clinical examinations and routine laboratory investigations for ITP. Genotyping for FcγRIIa was performed by using PCR-RFLP methods.
Results: the results reviled that mutant heterozygous (HR) were found to be significantly higher among ITP patients (57.5%) compared to the control group (10%) P