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302428

Detection of subclinical cardiac dysfunction in healthy medical workers with vitamin D deficiency

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Cardiology

Abstract

Background

Vitamin D is a necessary hormone in many tissues including cardiac myocytes. The autocrine and paracrine regulation of cellular growth differentiation and function in several organs depends on it through preventing the activation of the heart's renin-angiotensin system and natriuretic peptides vitamin d regulates calcium flux extracellular matrix turnover and myocardial contractility.

Our study aimed to identify the relationship between vitamin D deficiency and myocardial function in medical staff with nohistory of cardiac disease and normal transthoracic echo-Doppler parameters.

Methods

A comparative cross-sectional study involved 80 doctors, nurses, and technicians working at Zagazig University Hospitals; they were divided into two groups based on 25(OH) D levels: Group A (n=40) had a low vitamin D level of <20 ng/mL & Group B (n=40) had an average vitamin D level (>20 ng/ml). Both groups were subjected to conventional echocardiography and tissue Doppler imaging.

Results

The study found significantly higher Left ventricular and right ventricular Tei index in group A compared to group B (P value =0.01 and ˂0.001), respectively We also found a significantly higher tricuspid deceleration time (DT (t)), tricuspid lateral A' and significantly longer tricuspid interventricular isovolumetric relaxation time (IVRT(T) in group A compared to group B. Finally, a receiver operating characteristic (ROC) curve was performed which showed that 25(OH) D less than 19.5 was found to have 83% sensitivity and 65% specificity in determining a high RV tei index (>0.55).

Conclusions

Our study showed that Vitamin D deficiency affects both the systolic and diastolic function of the heart.

DOI

10.21608/zumj.2023.199367.2768

Keywords

Keywords: Vitamin D, cardiac function, Tissue Doppler imaging, TEI index

Authors

First Name

Elshaimaa

Last Name

Seaoud

MiddleName

Ali M.Elsadek

Affiliation

Department of Cardiology ,Faculty of Medicine,Zagazig University,Zagazig,44159,Egypt

Email

cardio_eg21@hotmail.com

City

-

Orcid

0000-0003-2082-2389

First Name

Moataz

Last Name

Elkot

MiddleName

A.

Affiliation

. Cardiology Department, Faculty of Medicine, Zagazig University, 44519, Zagazig, Egypt.

Email

mo3taz.elkot@gmail.com

City

-

Orcid

-

First Name

Seham

Last Name

Eldeeb

MiddleName

Mahmoud

Affiliation

public health and community medicine department, faculty of medicine, zagazig university mitghamr, dakahlia, egypt

Email

s.m.eldeeb@zu.edu.eg

City

-

Orcid

0000-0002-2015-3544

First Name

Shaimaa

Last Name

Wageeh

MiddleName

-

Affiliation

Cardiology Department, Faculty of Medicine, Zagazig University, 44519, Zagazig, Egypt.

Email

swkamel@medicine.zu.edu.eg

City

Zagazig

Orcid

0000-0002-4629-4791

Volume

29

Article Issue

4

Related Issue

42216

Issue Date

2023-07-01

Receive Date

2023-05-10

Publish Date

2023-07-01

Page Start

1,099

Page End

1,106

Print ISSN

1110-1431

Online ISSN

2357-0717

Link

https://zumj.journals.ekb.eg/article_302428.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=302428

Order

16

Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

Detection of subclinical cardiac dysfunction in healthy medical workers with vitamin D deficiency

Details

Type

Article

Created At

30 Dec 2024