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Keloids: Epidemiology, Histopathology, Mechanisms and Models of treatment

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Dermatology & Venereology

Abstract

Keloid is skin disorder of excess fibrous tissue deposition that usually follow a noxious insult to the skin. Irregular arrangement of connective tissue components together with exaggerated collagen deposition are noticed on histological examination of slides of keloid tissue. The definitive cause is not yet well-known. Diverse array of risk factors including family history and black race are thought to share in the development process. Because of unaccepted cosmetic appearance and negative impact on patient's quality of life, keloid is widely investigated by many researchers. The treatment panel of keloid include large number of treatment tools. Many substances are available for direct intra-lesional injection such as triamcinolone acetate and botulinum toxin A. Cryotherapy of the keloid can result in occlusion of small vessels and reduce its size. Other modalities of treatment include laser therapy and radiotherapy. Modalities of laser treatment include fractional laser or pulsed dye laser. Laser assisted drug delivery is a recently developed modality. Surgical scar revision is often associated with recurrence

DOI

10.21608/zumj.2022.110072.2425

Keywords

keloids, Triamcinolone acetonide, Laser

Authors

First Name

Zeinab

Last Name

Dawoud

MiddleName

Emad

Affiliation

Dermatology and Venereology Department, Al-Ahrar Teaching Hospital, Zagazig, Egypt

Email

zenab.e021@medicine.zu.edu.eg

City

Zagazig

Orcid

-

First Name

Enayat

Last Name

Atwa

MiddleName

Mohamed

Affiliation

Dermatology and Venerology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

drenayatattwa@yahoo.com

City

-

Orcid

-

First Name

Khaled

Last Name

Gharib

MiddleName

Mohamed

Affiliation

Dermatology and Venereology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

kh_gharib@hotmail.com

City

Zagazig

Orcid

0000-0002-1752-0171

Volume

29

Article Issue

4

Related Issue

42216

Issue Date

2023-07-01

Receive Date

2021-12-11

Publish Date

2023-07-01

Page Start

1,013

Page End

1,017

Print ISSN

1110-1431

Online ISSN

2357-0717

Link

https://zumj.journals.ekb.eg/article_213767.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=213767

Order

6

Type

Review Articles

Type Code

349

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

Keloids: Epidemiology, Histopathology, Mechanisms and Models of treatment

Details

Type

Article

Created At

30 Dec 2024