Background : Laryngoscopy and the endotracheal intubation are stressful situation for the patients, as these procedures are capable of producing tachycardia, hypertension and arrhythmias. Aim of work: The aim of the current study was to compare the effect of magnesium sulphate and two doses of dexmedetomidine on hemodynamic response to laryngeoscopy and tracheal intubation. Patients and methods: This comparative prospective randomized controlled (single-blind) clinical study was carried out in Zagazig University hospitals on 80 patients during the period from May 2019 to February 2020. Patients were divided randomly into four groups each is 20 patients: Group Da: 20 Patients received dexmedetomidine 0.5mcg/kg in 20 ml normal saline intravenous infusion over 10 min. Group Db: 20 Patients received dexmedetomidine 1mcg/kg in 20 ml normal saline intravenous infusion. Group M: 20 Patients received magnesium sulphate 30mg/kg in 20 ml normal saline intravenous infusion over 10 min. Group C: 20 Patients received 20ml 0.9% in 20 ml normal saline intravenous infusion over 10 min. Results: Heart rate in Db group were statistically lower than other groups, Heart rate in Da group were statistically significant lower compared to group M and group C. Systolic blood pressure were statistically significant lower in group Db compared to other group. Conclusion : Through this study, we can conclude that Dexmedetomidine 1mcg/kg is more effective than dexmedetomidine 0.5mcg/kg and magnesium sulphate 30mg/kg in decrease the hemodynamic response to laryngeoscopy and tracheal intubation.