Background: Diabetic nephropathy [DN], as a microvascular complication of both types of diabetes mellitus, is considered a leading cause of end-stage renal diseases in diabetic patients. Microalbuminuria is an early marker of diabetic nephropathy, but some diabetic nephropathy patients with early glomerular influence may present with a normal range of albumin in the urine. Our aim of study is to investigate the relationship between serum Osteoinductive factor and diabetic nephropathy, and its potential use as a diagnostic marker for DN in patients with type 1 DM. this study included a total of 60 type 1 diabetic patients divided to normoalbuminuria, microalbuminuria and macroalbuminuria groups , each group contained 20 patients.
Results: DM duration was significantly higher in macroalbuminuric and microalbuminuric patients than in normoalbuminuric subjects (P =0 .00).
Systolic and Diastolic Blood Pressure were significantly different among groups showing a higher level in microalbuminuric and macroalbuminuric than normoalbuminuric subjects (p=0.002). Dyslipidemia was significantly more evident in group III (p=0.00) . Macroalbuminuric patients were significantly associated with the highest s.creatinine and the lowest GFR; moreover, the highest level of UACR was significantly evident in the same group (p=0.00).OIF was positively correlated with DM duration, Creatinine and . OIF concentration in microalbuminuric and macroalbuminuric subjects were significantly increased than that in normoalbuminuric group (p=0.00). Significant area under curve(0.893) with significant cutoff [314.5] with sensitivity 80% and specificity 75.0% ,(p=0.00)