The Multiple Sclerosis (MS) disease is considered as chronic, demyelinating, immune –mediated disease of the central nervous system. The immunity mediated by T-lymphocyte plays the most effective destructive process in the CNS in MS. High levels of circulating soluble form of ICAM (sICAM-1) have been detected in the serum of MS patients . The biomarker neutrophil-lymphocytic ratio (NLR) is an index , had been reported to be cheap, readily available, and easy to measyre. The estimation of immunoglobulin M (IgM) bands, which seem to be predictive for a more severe disease course with a shorter time period to the next relapse, and higher grade of disability. Also, CRP elevated in response to inflammation as acute phase protein reactant and reported that CRP can be used as useful marker for the detection of inflammation-mediated MS. Aim of work: to estimate ICAM-1 levels in remitting-relapsing multiple sclerosis during remission and to evaluate it's correlation with neurological disability , and then assess correlation of some inflammatory markers (CRP, NLR ,IgM) with neurological disability in MS patients.