Background: Infectious complications in children with chronic kidney disease are a significant cause of increased rates of morbidity and mortality among these children. This study aimed to determine the diagnostic value of PCT and PSP as new markers of infection in Children with Chronic renal failure and to decrease morbidity and mortality rates in these children. Methods: This case control study was conducted on 36 patients diagnosed with Chronic Renal Failure and admitted at Nephrology Pediatric Unit, Children's Hospital, Zagazig University during the period from October 2018 to February 2019 were divided, first group 18 Children with CKD diagnosed with infectious complications, second group 18 (Control group). The serum expression of PTC and PSP was measured. Pearson correlation analysis was conducted to correlate PTC & PSP with each other and with CRP, Temp., HR, pus cells and blood culture. Results: The serum levels of PTC and PSP in Case group were higher than in control group (P22.8 ng/ml for PSP and >6.5mg/L for CRP with sensitivity 88.9%, 81.8% and 83.3% respectively and specificity 95.6%, 72.2% and 94.4% respectively. Conclusion: Serum levels of PCT and PSP are promising biomarkers of early detection of infectious complications in Children with Chronic renal failure.