Background: Serum iron and Vitamin D3, have vital roles in regulating numerous cellular processes in nervous system. Additionally, vitamin D3 could affect iron metabolism, iron in turn is essential for vitamin D3 formation. Even with the different studies, it is still unclear whether serum iron and/or Vitamin D3 have a role in the decline of cognitive function and progression of dementia.

Aim: to investigate serum iron and Vitamin D3 levels and their association with cognitive function in dementia patients in Zagazig University Hospitals

Methods: Sixty male and female patients; 30 control and 30 newly diagnosed dementia patients were included in the study. Cognitive function tests were performed. Serum analysis of iron, ferritin, TIBC and vitamin D3 were analyzed.

Results: dementia patients showed significant decrease in cognitive function tests, iron status parameters and vitamin D3. additionally, significant association between vitamin D3 and cognitive tests, also between vitamin D3, ferritin and TIBC was found. Furthermore, an association between serum iron, ferritin with some cognitive tests was statistically significant.

Conclusion: Serum iron status and vitamin D3 is associated with cognitive function decline in newly diagnosed dementia patients.