Background:
Chitinase-3-Like Protein 1(YKL140) is an inflammatory biomarker secreted from neutrophils, epithelial cells and smooth muscle cells of airways. It has been expressed in diseases characterized by inflammation and tissue remolding of respiratory tract .
Aim of the study:
The aim of study is to estimate serum YKL140 in wheezy infant and study its role in parthenogenesis and management.
Subject and methods:
The study was carried on 49 infants with wheezes , Complete blood count (CBC) with differential counts, C-reactive protien (CRP) , blood gases were done . Chest x-ray. C.T. scan were done when required for persistent wheezing, YKL-140 was assessed by enzyme linked immune assay kits .
Results:
Serum YKL 140 did not show any relation to NICU admission or recurrence of wheezing. Cases with family history of asthma showed higher level compared with those without family history. . Also critical cases showed higher values compared with stable cases .However cases without family history of wheezing and stable cases showed no difference in serum YKL 140 compared to control. No significant difference between cases and control regarding RBCs , platelets and CRP, while cases showed lower Hb and higher WBCs , neutrophil, serum YKL40 compared with control . Serum YKL140 showed positive correlation with neutrophil counts.
Conclusion:
Serum YKL140 was significantly higher in wheezing infants compared to control. Critical cases and cases with family history of asthma showed higher level compared with stable cases , those without family history of asthma. It showed positive correlation with blood neutrophil.