Abstract:
BACKGROUND: Proton MR spectroscopy (H1-MRS) is currently considered a useful technique for evaluating axonal damage and demyelination in MS, however, only few spectroscopic cervical MS study have been published because of the technical difficulties.
PATIENTS AND METHODS: twenty patients with multiple sclerosis were encountered in the study and subjected to clinical assessment including full history taking, clinical examination and imaging assessment by cMRI and functional MRI. We determined the metabolic profile of each case as regard to control group.
RESULTS: comparison of the main metabolites ratios between different studied groups (MS cord plaque group and control group), Cho/Cr, NAA/Cr, mI/Cr& NAA/Cho of control, acute MS, relapsing MS and progressive MS groups were 0.52±0.1, 0.62±0.08, 0.55±0.06, 0.59±0.02, 1.1±0.15, 1.3±0.02, 1.4±0.1, 0.9±0.03, 1.4±0.13, 2.3±0.2, 1.6±0.3, 2.08±0.04, 3.9±0.9, 2.0±0.04, 1.4±0.08 and 1.2±0.06 respectively with P value