Background: Systemic lupus erythematosus (SLE) is a chronic , acquired, autoimmune multisystemic disease. Homocysteine(HCys) plasma levels increase frequently in children with (SLE). Hyperhomocysteinemia (HHCys) represented a risk factor for many morbidities in SLE patients as the formation of atherosclerotic plaques and atherothrombotic events. Also hyperhomocysteinemia (HHCys) was found to be associated with dyslipidemia and vit D deficiency in these patients. This study aimed at measurement the level of homocysteine in children with SLE.

Method:
A retrospective case control study was carried out in pediatric department, Zagazig University hospital during the period from December 2016 to January 2018. 35patient diagnosed as SLE and 35 healthy controls were taken in the study. All participants were subjected to full clinical history taking, clinical examination and investigations as complete blood count(CBC),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),antinuclear antibodies( ANA), renal ,liver function ,lipid profile ,Vit D level and serum homocysteine level. statistical analysis was done for these data.
Results: Serum homocysteine level was significantly higher in children with SLE than control group (P