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180898

Cytokine Storm in COVID-19 Patients: Association between cytokines and disease severity

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Medical Biochemistry

Abstract

Objectives: To determine the cytokine storm profile in patients with COVID-19 infection in relation to the disease severity.
Methods: Serum levels of TNF-α, IFN-γ, IL-6 and IL-1β were measured by ELISA method and IL-1RII, TNFR1 and TNFR2 gene expression in peripheral blood mononuclear cells (PBMCs) were done using real time polymerase chain reaction (PCR) method in a total of 203 COVID-19 patients. The 1st group included 52 COVID-19 severe cases, the 2nd comprised 104 moderate cases and the 47 mild cases lied in the 3rd group.
Results: There was a significant association between degree of COVID-19 severity and IL6, TNF-α & IFN-γ serum levels (p < /p>

DOI

10.21608/zumj.2021.76794.2237

Keywords

COVID-19, interferon-γ (IFN-γ), Tumor Necrotizing Factor α (TNF-α), Interleukin 6 (IL-6), Cytokine receptors

Authors

First Name

Walaa

Last Name

Sarhan

MiddleName

M.

Affiliation

Medical Biochemistry &amp;amp; Molecular Biology department, Faculty of Medicine, Zagazig University

Email

walaasarhan@hotmail.com

City

-

Orcid

0000-0001-8098-1651

First Name

Sally M

Last Name

Shalaby

MiddleName

-

Affiliation

Medical Biochemistry Department-Faculty of Medicine- Zagazig University-Egypt

Email

sallyshalaby@hotmail.com

City

-

Orcid

0000-0002-2868-020X

First Name

Nahla

Last Name

Zidan

MiddleName

-

Affiliation

Clinical Pathology Department, Faculty of Medicine, Zagazig University

Email

tommedglis@yahoo.com

City

-

Orcid

-

First Name

Abeer

Last Name

Elhawary

MiddleName

-

Affiliation

Chest Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt

Email

dr_abeer@yahoo.com

City

-

Orcid

-

First Name

Nagwan

Last Name

Ismail

MiddleName

-

Affiliation

Chest Department, Faculty of Medicine, Zagazig University

Email

drhakim79@hotmail.com

City

-

Orcid

-

First Name

Vishruti

Last Name

Makani

MiddleName

-

Affiliation

Process Development Scientist, KBI Biopharma, Durham, NC, US

Email

tommedglis@gmail.com

City

-

Orcid

-

First Name

Hanim

Last Name

Abd elnour

MiddleName

Magdy

Affiliation

medical biochmestry and molecular biology department, faculty of medicine, Zagazig univerisity, Zagazig, Egypt

Email

hanemmagdy1982@gmail.com

City

Zagazig

Orcid

-

Volume

27

Article Issue

6

Related Issue

28516

Issue Date

2021-11-01

Receive Date

2021-05-19

Publish Date

2021-11-01

Page Start

1,640

Page End

1,653

Print ISSN

1110-1431

Online ISSN

2357-0717

Article File

ZUMJ_Volume 27_Issue 6_Pages 1640-1653.pdf

PDF . 1.2MB

Link

https://zumj.journals.ekb.eg/article_180898.html

Detail API

https://zumj.journals.ekb.eg/service?article_code=180898

Order

752

Type

Original Article

Type Code

273

Publication Type

Journal

Publication Title

Zagazig University Medical Journal

Publication Link

https://zumj.journals.ekb.eg/

MainTitle

Cytokine Storm in COVID-19 Patients: Association between cytokines and disease severity

Details

Type

Article

Created At

30 Dec 2024