Introduction: Congenital heart diseases are among the most common birth defects and are the leading cause of birth defect-related deaths. In Egypt, it was found that the prevalence of congenital heart diseases was 1.01/1,000 live births. The most common cardiac defects are ventricular septal defects. Children with congenital heart diseases experience decreased health related quality of life. Aim: This study aimed at improving health-related quality of life of the children  through applying an educational program about the most important aspects of the disease and how to deal with it. Subjects and methods: An intervention study (pre-post self-control study) was carried out on 54 patients aged  (10 – 18 years) with congenital heart diseases by providing health education session to the patient and their parents.The patients were assessed using PedsQL Pediatric Quality of Life Inventory Version 4.0 and PedsQL Cardiac Module Version 3.0 to assess health related quality of life before and after intervention. Results: This study showed that patient education intervention caused significant improvements in all quality of life domains among the patients. Conclusion: Patient education is considered a very effective method that could be applied by health care providers in order to improve the quality of life of children  suffering from congenital heart diseases.