Abstract Background: Assessment of myometrial invasion in pa-tients with endometrial carcinoma could be done by magnetic resonance imaging (MRI) study. Several studies have demon-strated that combining DWI with T2 weighted MRI plays an important role in the detection the depth of myometrial invasion and staging of endometrial carcinoma. Aim of Study: The aim of this study is to evaluate the role of the combined T2WI and DWI in assessment of the depth of myometrial invasion and staging of endometrial carcinoma at the preoperative staging. Patients and Methods: Thirty eight cases were included; patients referred to Radiology Department of Mansoura Uni-versity Hospital. There were postmenopausal female patients with age ranged from 53 to 76 years. All patients were subject-ed to proper history taking and DWI and T2 MRI. This study was using a 1.5 T Philips Ingenia MRI scanner. Results: There is statistically significant difference be-tween myometrial invasion in pateients with endometrial car-cinoma by T2 MRI, Dynamic contrast enhanced (DCE) MRI, DWI MRI regarding the pathology results. Combination of T2 and DWI MRI in assessment of myometrial invasion in patients with endometrial carcinoma has accuracy, sensitivity, speci-ficity, PPV and NPV of 94.7%, 86.7%, 100%, 100% and 92% respectively. Conclusion: DWI is important complementary, and sup-plementary tools to T2 MRI, not replacing, and thus; It should be done as routine image modality side by side to conventional imaging for assessment of myometrial invasion in cases of en-dometrial carcinoma.