Abstract Background: Bronchial asthma is an important global health problem which affects all age groups, and its prevalence is increasing in many countries, especially among children. Aim of Study: The aim of this study is to define hypotha-lamic pituitary adrenal axis suppression (HPAS) in asthmatic children. Subjects and Methods: This study was a cross-sectional study has in pediatric chest and outpatient clinics at Children's Hospital, Ain Shams University, Cairo, Egypt (1 year duration) during the period from November 2022 to November 2023. This study was carried out on 35 asthmatic pediatric patients aged from 3-10 years old with documented asthma diagnosis. Results: The presenting respiratory symptoms for studied patients as 21 (60%) were presented by cough, 9 (25.7%) were presented bydyspnea, 25 (71.4%) were presented by wheezes and 14 (40%) were presented by exercise intolerance. Serum Cortisol (PM) level were with median 167.65 (110.84-247.97) with range (110.2-538.1). Conclusion: Median serum Cortisol (PM) level was 167.65 with range (110.2-538.1).