Abstract Background: The largest internal organ of the human body, the liver produces the most vital chemicals required for surviv-al. Hawthorn fruits are considered one of the plants that most help remove hepatotoxicity, and not only that but also improve the functional state of the liver, as we will notice from the pres-ent research. Aim of Study: Know the effectiveness of hawthorn fruits in improving biochemical changes in hepatic rats. Material and Methods: Twenty-four male albino mice, specifically Sprague-Dawley breed, were utilized in the pres-ent investigation. Each group comprised six mice, & all mice were provided with a basal diet for one week before the start of the research. For twenty-eight days, the initial main group sam-ple of control negative normal mice (C–ve) was provided with only the basal diet. Rats comprising the 2nd main group (n=18) were injected with Ccl4. This the primary group was further separated into 3 subgroups, one of which was administered a basal diet without any kind of therapy, serving as the control positive group (C+ve). Two group of this subgroup were fed a basal diet added with varying concentrations of hawthorn fruits (10% & 15%). The findings indicated that group four consisting of hepatic mice fed fifteen percent hawthorn fruits, exhibited superior serum high-density lipoprotein cholesterol levels in comparison to the control group (–). Additionally, group four (15% hawthorn fruit). Results: Serum ALP & GPT, had a non-significant variance in GPT activity when compared to the group of healthy mice. The optimal therapy, as determined by the CAT to GPX ratio, was identified for group 4. Conclusion: The fruits of the hawthorn plant are consid-ered one of the plants that have a therapeutic and preventive effect on many diseases, especially liver diseases. The reason for this is that hawthorn fruits have a significant number of fla-vonoids & phenolic compounds.