Background: Minimally invasive endovascular techniques have become crucial in medical practice for treating various vascular disorders. These techniques utilize the blood vessels as pathways to reach distant areas, allowing for precise admin-istration of medications like chemotherapy or radiation thera-py. However, there are challenges that hinder a more extensive adoption of an all-endovascular approach, including the com-
plexity of vascular anatomy, difficulty accessing small blood vessels, vulnerability of diseased vessels, need for emergency procedures, prolonged exposure to X-ray radiation, and pa-tient-specific factors like coagulopathy. Fresh innovations are needed to overcome these limitations.
Aim of Study: This study aims to explore the current status of small-scale robots in endovascular applications. It compares their potential benefits to existing tethered clinical devices and delves into technological obstacles and clinical specifications necessary for the practical implementation of untethered robots inside blood vessels. Methods: The methods used in this study involve a com-prehensive review and analysis of the existing literature on small-scale robots in endovascular applications. The review includes an examination of their potential benefits, comparison
with tethered clinical devices, and identification of technologi-cal and clinical requirements for practical implementation. Results: The study highlight the potential benefits of small-scale robots in endovascular applications, including improved precision, wireless control, and autonomous operation. A com-parison with tethered clinical devices reveals the advantages of untethered robots. However, there are technological obstacles and clinical specifications that need to be addressed for the practical implementation of these robots inside blood vessels  Conclusion: In conclusion, small-scale robots show prom-ise for advancing minimally invasive endovascular treatments. They have the potential to overcome existing limitations and establish new benchmarks. However, further technological ad-vancements and consideration of clinical requirements are nec-essary for their practical implementation.