Abstract Background: Cystic fibrosis (CF) is a complex and system-ic disorder which is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The ab-sence of CFTR and the cAMP-regulated anion channel results in the manifestation of disease, such as failure to thrive and malnutrition. Aim of Study: This study aimed to asses growth hormone levels in CF children. Patients and Methods: This is a case-control study was conducted on 20 cystic fibrosis patients who were compared to 20 apparently healthy control participants. Results: There were no significant differences between pa-tients with normal and low growth hormone levels as regard presenting symptoms or signs. Conclusion: The current results: Growth hormone might decrease in cystic fibrosis children.