Abstract Background: Hemorrhoids represent one of the most com-mon colorectal complaints heard by family physicians. One fourth of those patients consult a surgeon. One of the most com-mon symptom is anal pain. Hemorrhoids also may thrombose, causing severe pain. Aim of Study: Comparison of the post-operative pain post open and stapling method. Patient and Methods: This study was carried out as a Prospective randomized controlled study among 30 patients presented for the Surgical department, unit-25 Cairo Univer-sity Hospital for surgical treatment of hemorrhoids grade third and fourth. 15 patients doing conventional hemorrhoidectomy and 15 patients doing stapling hemorrhoidectomy. Pain Rating Scale: A linear analogue pain scale from 0 to 10 was used to evaluate pain, where 0 corresponded to no pain and 10 to the worst pain imaginable. Results: Mean age was 42.07 years in open hemorrhoid-ectomy group versus 41.4 years in stapled hemorrhoidectomy group with no statistically significant difference. Most of pa-tients in both groups were males.pain score among both groups. It was found that immediately postoperative, mean pain score was 7.4 among open hemorrhoidectomy group patients versus 6.87 among stapled hemorrhoidectomy group patients with no statistically significant difference. When re-evaluated 24 hours postoperative mean pain score was found to be as low as 3.27 among open hemorrhoidectomy group patients versus 3.07 among stapled hemorrhoidectomy group patients but still with no statistically significant difference between both groups. Comparing pain score among paints of each group. It was found that pain score has decreased significantly after 24 hours post-operative compared to immediate postoperative value in both groups with statistically significant difference. Conclusion: Stapled hemorrhoidectomy has some advan-tages over conventional hemorrhoidectomy including shorter duration of surgery, shorter duration of hospital stay, faster postoperative return to work, and lower postoperative pain with statistically significant difference.