Abstract Background: Mastectomy, in which breast tissue is surgi-cally removed, can cause physical, mental, and social issues for patients Some of the major side effects included infection, pain, phantom breast disorder, seroma, hemorrhage lymphede-ma, as well as frozen shoulder. Aim of Study: The goal of the study is to compare the thera-peutic impact between low level laser versus bee venom phono-phoresis on shoulder dysfunction in postmastectomy patients. Patients and Methods: Fifty-two patients took part in this study. They were aged from 30 to 55 years. They were selected from Alexandria Police Hospital and randomized into 2 groups equal in number. Group (A): 26 patients were given 20min low level laser therapy 3 sessions per week as well as selected physiotherapy program according to Canadian Cancer Society Guidelines for 6 weeks. While, Group (B): 26 patients were given 10min bee venom phonophoresis 3 sessions per week as well as selected physiotherapy program according to Canadian Cancer Society Guidelines for 6 weeks. Results: This study demonstrated that there was a statisti-cally highly significant enhancement in Visual analogue scale and shoulder Range of motion of group (A) when compared with its corresponding value in group (B). Conclusion: The use of low-level laser therapy was more beneficial than bee venom phonophoresis in improvement shoulder pain as well as ROM in postmastectomy patients