Abstract Background: Pseudophakic cystoid macular edema (PCME) is an important cause of drop of visual acuity after phacoemulsification especially in complicated cases, studies have focused on the ability of non-steroidal anti-inflammatory drops (NSAIDs) to prevent PCME. Aim of Study: This study aimed at evaluating the NSAIDs in prevention of PCME in phacoemulsification patients compli-cated by vitreous loss. Patients and Methods: This study included 40 eyes of 40 patients complicated with vitreous loss, 20 of them received standard treatment and the other 20 received the standard treat-ment in addition to NSAIDs, each patient underwent assess-ment of BCVA and OCT macula scanning at 1st week and 1st month. Results: This study found that NSAIDs attained better BCVA values when compared to patients who received the standard treatment only, they also recorded lower CMT thick-ness, however there were no significant difference between the 2 groups when patients with intraretinal cystoid changes were excluded. Conclusion: At 1 month postoperative, patients who re-ceived NSAIDs had significantly better BCVA and did not de-velop intraretinal cysts.