Abstract Background: Malaria is a major health threat in Yemen, and it is the most common and widely prevalent life-threatening infectious disease in tropical and subtropical regions where it causes high rates of morbidity and mortality. Aim of Study: This study aimed to describe the clinical and demographic profile, and outcome of patients with malaria including complicated Cases with focusing on cerebral malaria, hepatic and renal impairment admitting in Al-Gamhouria Teaching Hospital and attending a private clinic Aden City in Southwest Yemen. Patients and Methods: It was a prospective study, a total of 30 malaria patients >15 years of age who presented in Al Gamhouria Teaching Hospital and a private clinic in Aden City Southwest of Yemen, over a period of one year, Between (June 2022to June 2023), rapid diagnostic test used for malaria diagnosis, clinical examination and other laboratory tests to identify severe malaria complications with focusing on cerebral malaria, hepatic and renal impairment were performed at the hospital and the clinic. Results: During the study period, 30 patients were enrolled, (83%) of cases were male while (17%) being female, mean age was (30±15.2) years, (50%) of patients belonging to the age group of (26-35) years, (80%) came from rural area while (20%) came from urban area, Fever was the most common symptoms of malaria (93%) cerebral malaria was the most common complication (30%), recovered patients was (83%) while dead patients (17%). Conclusion: This study concluded that the majority of patients were male and came from rural area, fever was the most common symptoms while cerebral malaria was the most common complication.