Abstract Background: Impaired subclinical left atrial (LA) function may contribute to the risk of cardiovascular disease in obesity. Aim of Study: To highlight the effect of obesity on LA strain in patients with a structurally normal heart. Subjects and Methods: This is a prospective case-control study performed in El Demerdash Hospital echocardiography unit. This study included fifty nonobese subjects (BMI <30kg/m2) as controls, and the other 50 obese subjects (BMI >30kg/m2) as cases. Results: On assessing left atrial measurements and func-tions, max and min LA volume by Biplane method by Speckle tracking echocardiography (STE), indexed volumes and LA EF by Biplane method showed no significant difference between the non-obese group and obese group (p>0.05). Moreover, there was no statistically significant difference between the two groups regarding all the LA strain values (p>0.05). Conclusion: Obesity has no effect on the LA reservoir, contractile, or conduct strain by 2D speckle-tracking.