Abstract Background: After lung cancer, breast cancer is the most frequent cancer among women and the second greatest cause of cancer death. Aim of Study: The rate and causes of breast conservative surgery conversion to mastectomy in early breast cancer versus down staging after neoadjuvant treatment are identified. Patients and Methods: During this study, 40 females with breast cancer were enrolled and divided into two groups. All patients were subjected to conservative breast surgery and intraoperative frozen section; 20 patients with early breast cancer andanother 20 patients who received neoadjuvant therapy. All patients were subjected to history taking, clinical examination, radiologic investigations, core biopsy, preoper-ative laboratory investigations and histopathological exami-nation of excised mass. Results: There were no statistically significant differences between study groups as regard rate of conversion to mastec-tomy, frozen results, post-operative compilations and response and Clipping distribution. Conclusion: The rate of conversion to mastectomy, frozen results, post-operative compilations and response, and clipping distribution were similar in cases of early breast cancer and late stages subjected to neoadjuvant down staging treatment. As a result, all cases of late breast cancer were down staged using neoadjuvant therapy rather than undergoing mastectomy.