Abstract Background: Pancreatic cysts involve a wide spectrum of pathologies, including non-neoplastic post-inflammatory cysts as well as benign and malignant neoplastic cystic tumors. Pancreatic cystic lesions are classified according to epithelial lining into true cysts (lined with the epithelium) and pseudo-cysts (without the epithelium). There are multiple imaging modalities in the diagnosis of pancreatic cancer, such as CT, EUS, and MRI. Aim of Study: This study aims to evaluate the diagnostic accuracy of EUS and CT versus MRI in the detection of pancreatic cystic lesions. Patients and Methods: Patients with epigastric pain sug-gestive of pancreatic origin who were referred from an out-patient clinic of the Endemic Medicine Department and the Endosonography Unit between April 2021 and September 2021 underwent magnetic resonance imaging and were divided into two groups based on their findings (33 patients with pancreatic cysts, who will act as the case group, and 34 patients with chronic pancreatitis and pancreatic stones as the control group). Results: For the findings, the average age of the case patients was 43.9 years, with 55% being female. In contrast, the average age of control cases was 49 years, with 56% being male. We discovered that CT was more sensitive and specific than EUS in detecting the type, location, and size of pancreatic cysts, vascular invasion, and lymphatic affection in Case Group. In contrast, EUS was more sensitive than CT in the diagnosis of chronic pancreatitis and pancreatic stones in the control group. Conclusions: Based on our findings, we can conclude that CT is more sensitive than EUS in the diagnosis of pan-creatic cysts and that there is no significant difference in the detection of pancreatic cysts between CT and MRI. In terms of the control group, we discovered that EUS was more sensitive than CT at detecting chronic pancreatitis and pan-creatic stones.