Abstract Background: Chronic obstructive pulmonary disease (COPD), which is a leading cause of mortality and morbidity worldwide, is the main cause of persistent obstruction of the airway leading to respiratory muscle weakness. Aim of Study: Comparing the response of pulmonary functions to resisted inspiratory muscles training versus pneumatic compression in COPD patients. Patients and Methods: Randomized prospective clinical study included 40 patients with moderate and sever COPD. They were recruited from outpatient clinic of chest disease, Benha University Hospital; patients were randomly assigned into two equal groups, group A received Inspiratory Muscle Training (30% of maximum inspiratory pressure) and group B received Pneumatic Compression with abdominal sleeve (30% of one-repetition maximum). All patients trained 3 times per week for 12 weeks. Respiratory function tests were compared before interventions and post 12 weeks. Results: Comparison between groups post treatment revealed a significant increase in FEV 1, FVC, PEFR, FEF25- 75% and 6MWT of group A compared with that of group B (p<0.05). Conclusions: Inspiratory muscle training and pneumatic compression improve pulmonary functions and pneumatic compression can be considered as an effective component for pulmonary rehabilitation in COPD patients.