Abstract Background: Lumbar discectomy is one of the most commonly performed surgical procedures of the lumbar spine. Interlaminar discectomy is becoming the mainstay approach for excision of a herniated lumbar disc as it provides a mini-mally invasive approach that preserves the normal spine anatomy. Aim of Study: This study aimed to compare the outcome of interlaminar lumbar discectomy to the conventional open approach for cases with lumbar disc prolapse. Patients and Methods: This is a single-blinded randomized controlled study of 20 patients, divided into two groups. Group A were operated upon by conventional open lumbar discectomy and Group B were subjected to the interlaminar approach Results: Our results showed a marked reduction in post-operative back pain VAS of the interlaminar group, together with a shorter hospital stay (1.80±0.92 days) and faster return to work (13.9±3.03 days) when compared to the conventional approach, with a similar complication rate. Conclusion: Interlaminar lumbar discectomy is a safe and effective approach for treatment of lumbar disc herniation and provides a better preservation of the normal spine anatomy and a faster recovery.