Background: Knowledge brokers (KBs) collaborate with important stakeholders to enable the transmission and exchange of information in a specific environment. At present, there is a widely held belief that there is insufficient data about the ef-ficacy of knowledge brokering and the elements that impact its performance as a method for knowledge translation (KT). Aim of Study: The objective of this research was to compre-hensively collect information on the characteristics of knowl-edge brokering in health-related environments and assess the effectiveness of knowledge brokers in facilitating knowledge translation in these contexts. Methods: A comprehensive evaluation was performed us-ing a search technique devised by a librarian specialized in health research. A comprehensive search was conducted in eight electronic databases (MEDLINE, Embase, PsycINFO, CINAHL, ERIC, Scopus, SocINDEX, and Health Business Elite) as well as relevant grey literature sources, with a focus on English language materials. Two reviewers autonomously evaluated the abstracts, examined whole publications, extracted data, and conducted quality evaluations. The analysis used a confirmatory thematic method. In order to be eligible, the re-search must have taken place in a health-related environment, documented a practical implementation of knowledge broker-ing, and be accessible in the English language. Results: The findings demonstrated that knowledge brokers (KBs) carried out a wide variety of duties in various health-related environments. The results provided evidence for the function of KBs as knowledge managers, linking agents, and capacity builders. In this review, we analyzed outcome data from a specific group of studies (n=8) to identify any evidence of changes in knowledge, skills, and policies or practices as-sociated with knowledge brokering. Two researches adhered to rigorous methodological criteria, resulting in equivocal data about the efficiency of KB. Conclusion: In conclusion, KBs, as knowledge managers, linkage agents, and capacity builders, carried out several du-ties to facilitate the transmission and sharing of information across stakeholders, contexts, and sectors relevant to health. The extent to which they successfully carried out their func-tion in enabling knowledge translation processes is uncertain; further rigorous study is necessary to address this subject and determine the potential influence of knowledge brokers on edu-cation, practice, and policy.