Abstract Background: Enterocutaneous fistulae is a result of a wide variety of conditions and circumstances. Care of these patients can be quite challenging, frustrating, and, ultimately, rewarding. Aim of Study: Assessment of role of vacuum assisted closure in management of patients with post-operative entero-cutaneous fistulae. Patients and Methods: This is a prospective cohort study that will be conducted on fifteen (15) patients presenting to Ain Shams University Hospital and Cairo Fatemic Hospital (CFH) suffering from Enterocutaneous fistulae. Patients will be assessed according to inclusion and exclusion criteria. All patients sharing in the study will be fully informed about the procedure they will have, its possible squeal, and its compli-cation with a written and informed consent will be taken from all patients who will accept to participate. Results: In our study we found that 80% of patients had complete cure. Also vac system improve general condition and decrease skin excoriation. Vac system is a promising technic in management of ECF. Conclusion: Enterocutaneous fistulae is a common surgical problem result of a wide variety of conditions and circum-stances. Fistula management can be quite challenging, frus-trating, and, ultimately, rewarding. Different methods of management are found with different results and outcomes Vac therapy is a new technique with promising results in management of fistula Vac therapy improve fistula condition, decrease soiling, improve general condition and better finan-cially than ordinary dressing.