Abstract Background: In this study we wanted to evaluate the effect of blood cupping on liver function tests (also known as a liver panel) are blood tests that measure different enzymes, proteins, and other substances made by liver. These tests check the overall health of our liver. Also showing how hijamah can help in treating some liver diseases. Aim of Study: The aim of this study was to determine the effect of cupping therapy on hematological parameters and inflammatory proteins in elderly. Patients and Methods: Thirty volunteer patients have been selected from outpatients at Desouk General Hospital. Their age ranged from 60-70 years. They were assigned into one group toattended a program of cupping therapy once per month for three months. Results: The results of inflammatory proteins, showed that there were significantly differences (p=0.0001; p<0.05) in total protein, albumin, high sensitive C reactive protein, and interlukein-10 in addition to hematological factors of blood, in erythrocyte sedimentation rate, hemoglobin, total white blood cells, neutrophils, lymphocytes, monocytes, eosinophils, and basophils among pre-treatment, after 1- month, 2-month, and 3-month of cupping. No change in hemoglobin, neutrophils, and lymphocytes at baseline (pre-treatment) and after-cupping. There were significant differences (p<0.05) in mean difference total white blood cells, eosinophils, and basophils between pre-treatment vs. after 1-month, pre-treatment vs. after 2-months, but no significant differences (p>0.05) between pre-treatment vs. after 3-months. Conclusion: Cupping therapy have a good effect for elderly patients as an alternative treatment for patients who have hematological parameters and inflammatory proteins issues.