Abstract Background: Surgical management of cancer patients with macromastia holds some issues for surgeons. There are variable oncoplastic options that can be offered for management of each tumor site in relation to the size of the breast. Onco-plastic breast surgery may also include a contralateral reduction mammoplasty to attain symmetry, which may increasethe probability of wound complications. Aim of Study: The aim of this study were to determine the frequency and types of complications in Egyptian Ladies who underwent therapeutic reduction mammoplasty for breast cancer and detection of possible risk factors and methods of management. Patients and Methods: This study was a retrospective study implemented in Mansoura oncology center, where the data of all therapeutic mammoplasty patients between July 2017 till Janurary 2020, were analyzed. We abstracted the complications that occurred to those patients who underwent therapeutic reduction mammoplasty. Also, follow-up visits and survival were recorded. Results: A total of 87 women underwent 141 oBCS (54 cases underwent a contra lateral symmetrization). Complica-tions occurred in 29 cases (around 33% of the cases). Risk factors for complications occurrence was DM, HTN and nodal infiltration with no statistical significance (p=0.23, 0.47, 0.56 respectively). Conclusion: While oncoplastic breast surgeries may show a higherrate of complications, there were no significant delay to adjuvant therapy as well as risk of local recurrence.