Abstract Background: Ageing refers to a multidimensional process of physical, psychological, and social change. Fructose is widely used in foods and beverages because of its high relative sweetness. Soybean oil is one of the most widely consumed cooking oils; also, coconut is a part of the daily diets of many people. Aim of Study: The aim of this study was to demonstrate the histological and immunohistochemical changes that may be induced by aging, high-fructose dietsand high-fat dietsin pancreatic Islets of Langerhans in albino rats. Material and Methods: This study was conducted on 40 albino rats, divided into 4 groups. Group I or Control grou-preceived normal diet and were sacrificed by age of 2 months. Group II (aging group) that received a normal diet. Group III: That received normal diet in addition to fructose for one month. Group IV: That received normal diet in addition tococonut and soya bean oil dailyfor 1 month. Animals in group II, III and IV were sacrificed at the age of 12 months. After being sacrificed, their pancreases were extracted and prepared for light microscopic, electron microscopic and immunohistochemical studies. Results: It was found that aging was associated with degenerative changes in the Islet cells of Langerhans of the pancreas in albino rats and these changes were aggravated by concomitant consumption of high fructose or high fat diets. Conclusion: Diets rich in fructose and/or fats may exac-erbate aging-induced degenerative changes in the pancreatic Islet of Langerhans. Accordingly, it is recommended to keep consumption of fructose and fats at a reasonable level.