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347873

The Outcome of Patients with Cerebral Arteriovenous Malformations (AVMs) Treated with Stereotactic Radiosurgery (SRS) Using the CyberKnife (Rationale, Benefits and Risks): A Real

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Last updated: 01 Jan 2025

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Abstract

Background: Cerebral arteriovenous malformations (AVMs) are complex, heterogeneous, uncommon lesions that carry a high risk of intracranial hemorrhage with subsequent disability.
Aim: To evaluate the outcome of patients with cerebral AVMs treated in our center, King Faisal Specialized Hospital and Research Center (KFSH&RC) Saudi Arabia with SRS using the CyberKnife.
Methods: Medical records of patients treated in the above-mentioned way in the period between 2009-2021 were retrospectively evaluated.
Results: A total of 51 patients were included in this study. The median age at diagnosis was 31 (3-77) years. Neurological alteration and intracranial hemorrhage were the most common presentations in 24 (47.1%) patients. The mean maximum AVM nidus diameter and volume were 2.9 cm and 5.9 cc respectively. All the patients received SRS using CyberKnife with a median marginal dose of 20 (14-21) Gy over a single fraction. Volume staged treatment was applied in 4 (7.8%) patients. After a median follow-up of 37 (2-170) months, all patients were alive with successful obliteration of the AVM nidus occurring in 31 (60.8%) patients after a median latency period of 27 (4-68.9) months in those who achieved complete obliteration. No patients developed post-SRS hemorrhage and 11 (21.6%) patients developed post-SRS radiological radiation-induced changes of which only 3 (27.3%) patients were symptomatic (in the form of uncontrolled seizures). only SRS dose > 19 Gy was significantly correlated with the obliteration rate, as 79.3% of patients who received SRS dose > 19 Gy achieved obliteration vs 36.4 % only in those who received dose Conclusion: SRS treatment using CyberKnife is effective management for patients with cerebral AVMs without an increase in the incidence of post-SRS hemorrhage, stroke, or death.

DOI

10.21608/resoncol.2024.258069.1204

Keywords

arteriovenous malformations, CyberKnife, stereotactic radiosurgery

Authors

First Name

Ahmed

Last Name

Awad

MiddleName

A.

Affiliation

Section of Radiation Oncology, Oncology Center, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia , Radiation Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt

Email

ahmedawad@kfshrc.edu.sa

City

-

Orcid

-

First Name

Ameen

Last Name

Alomair

MiddleName

S.

Affiliation

Section of Radiation Oncology, Oncology Center, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

Email

ameenomair@kfshrc.edu.sa

City

-

Orcid

-

First Name

Mohammed

Last Name

Rizwanullah

MiddleName

M.

Affiliation

Section of Radiation Oncology, Oncology Center, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

Email

rmohamedmoniullah@kfshrc.edu.sa

City

Riyahd

Orcid

-

First Name

Adnan

Last Name

Alhebshi

MiddleName

S.

Affiliation

Radiation Oncology Department, Johns Hopkins Aramco Health Care, Dhahran, Saudi Arabia

Email

adnanhebshi@gmail.com

City

-

Orcid

-

First Name

Amr

Last Name

Taha

MiddleName

-

Affiliation

Radiation Oncology Department, King Fahad Specialist Hospital, Buraydah, Saudi Arabia , Radiation Oncology Department, National Cancer Institute, Cairo University, Cairo, Egypt

Email

amrgabermousa@yahoo.com

City

-

Orcid

0000-0002-7564-077X

First Name

Faisal

Last Name

Alzorkany

MiddleName

S.

Affiliation

Biomedical Physics Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

Email

falzorkany63@kfshrc.edu.sa

City

Riyahd

Orcid

-

First Name

Mohammed

Last Name

Alkafi

MiddleName

A.

Affiliation

Biomedical Physics Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

Email

mal-kafi@kfshrc.edu.sa

City

Riyahd

Orcid

-

First Name

Joti

Last Name

Phattacharya

MiddleName

-

Affiliation

Intervention Radiology Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia

Email

jphattacharya@kfshrc.edu.sa

City

-

Orcid

-

First Name

Ahmed

Last Name

Elashwah

MiddleName

M.

Affiliation

Section of Radiation Oncology, Oncology Center, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia , Department of Clinical Oncology and Nuclear Medicine, Kasr Al-Ainy Faculty of Medicine, Cairo University, Cairo, Egypt

Email

ashwah_a80@yahoo.com

City

-

Orcid

-

Volume

20

Article Issue

1

Related Issue

48686

Issue Date

2024-06-01

Receive Date

2023-12-25

Publish Date

2024-06-01

Page Start

1

Page End

8

Print ISSN

2357-0687

Online ISSN

2357-0695

Article File

RESONCOL_Volume 20_Issue 1_Pages 1-8.pdf

PDF . 221.1kB

Link

https://resoncol.journals.ekb.eg/article_347873.html

Detail API

https://resoncol.journals.ekb.eg/service?article_code=347873

Order

1

Type

Original Article

Type Code

200

Publication Type

Journal

Publication Title

Research in Oncology

Publication Link

https://resoncol.journals.ekb.eg/

MainTitle

The Outcome of Patients with Cerebral Arteriovenous Malformations (AVMs) Treated with Stereotactic Radiosurgery (SRS) Using the CyberKnife (Rationale, Benefits and Risks): A Real

Details

Type

Article

Created At

30 Dec 2024