The trial was conducted during the four successive seasons of 2019, 2020, 2021, and 2022 in a vineyard in the El-Khatatba region, Minufyia Governorate, Egypt to study the influence of Irrigation scheduling and hundz soil substance to improve water use efficiency, vegetative growth, fruit quality and yield of Flame Seedless grapevines grown in sandy soil. Seven-year-old vines were chosen, spaced at 2 x 3 meters, irrigated by the drip irrigation system, and trellised by the Spanish Parron system. The experiment was designed to study the effects of different rates from soil conditioners, Hundz soil, (0.5, 1, 1.5 and 2 kg/vine) under irrigation levels at 70, 85, and 100% IWR. Hundz soil was applied to the soil under drip irrigation lines yearly. The Results showed that the crop water consumptive use and irrigation water productivity were highest by increasing irrigation level and handz soil rate, and the addition of hundz soil substances 2 kg/vine plus an irrigation level at 85%IWR was effective in improving bud burst, bud fertility percentage, shoot length, number of leaves /shoot, and leaf area as well as enhancing yield per vine, cluster weight, berry weight, soluble solids content, total anthocyanin, and improved water use efficiency while reducing total acidity in berries compared with irrigation level alone in four seasons of study. Additionally, it can save about 15% of water to achieve the same yield and fruit quality, according to the availability of water due to addition of hunz soil substances, especially under drip irrigation.