Because of its climate diversity, the Kingdom of Saudi Arabia (KSA) has a very diverse range of plants many are traditionally used for the treatment of some infections. Current Knowledge of many Saudi medicinal plants that are useful in preventing infections by pharmacological means is presented in this study. For all information, the databases of Science Direct, Scopus, PubMed, Elsevier, Springer, and relevant research publications were consulted. It demonstrates the effective plant part with its family, the solvents used for extraction, the tested pathogenic microbes, and the antimicrobial effect indicated by inhibition zones and/or minimum inhibitory concentrations. This review highlights the significance of ethnobotanical uses of medicinal plants against various pathogens. The study reported a total of 79 medicinal plant species belonging to 26 families of which 90% are Dicot and 10% are Monocot. Most of the reported medicinal species (13%) belong to Asteraceae. Among studied bacterial pathogens, the majority of the documented ethnobotanical research focused on the effects of different plant extracts against Staphylococcus aureus (30%) while Candida albicans represented the most studied fungi (69%). Data analysis was conducted to show how to use these results in the future, however, more investigation is still required to confirm the safety and therapeutic use of many of these plants using phytochemical and toxicological analyses.