The bryoflora of the Setifian High Plains, which situated in the Northeastern region of Algeria is poorly known. Megriss Mountain is one of the most important ecosystems in this region. The examination of Orthotrichaceae samples collected during bryophytes diversity investigations in the northern part of Megriss resulted in the identification of the epiphytic species; Orthotrichum macrocephalum F. Lara, Garilleti & Mazimpaka. The identification was made based on its leaves with rounded or obtuse apices, recurved margins, pluripapillose laminal cells, the presence of propagules, emergent capsule with eight longitudinal orange ribs and star-shaped mouth when dry, scarcely constricted below the mouth, immersed stomata in the capsule wall and the papillose endostome segments. This acrocarpous moss with a marked affinity for the Mediterranean climate has never been recorded in the Algerian bryoflora. A comprehensive description, microphotographs, and distribution map in Algeria of this species are provided. Moreover, its ecology is also discussed.