This research was conducted during the 2022 season to study the effect of foliar application of chelated Nano-Copper , and their interaction with a number of spraying times on vegetative growth of yield of Taifi grape cv. (Vitis vinifera L.). Chelated Nano-Copper was sprayed at four concentrations 0, 1 , 1.5 and 2 g l-1. The result showed the superiority of the spraying with 1.5 g l-1 in traits of leaf area, total chlorophyll, number of clusters, berry weight, cluster weight and yield of grapevine. Furthermore, spraying three times achieved the best results for the leaf area, total chlorophyll, number of clusters, berry weight, cluster weight and yield of grapevine per vine. Foliar application of Chelated Nano-Copper was and number of spraying times achieved a significant increases in vegetative growth and the yield parameters compare to the control. This research was conducted during the 2022 season to study the effect of foliar application of chelated Nano-Copper , and their interaction with a number of spraying times on vegetative growth of yield of Taifi grape cv. (Vitis vinifera L.). Chelated Nano-Copper was sprayed at four concentrations 0, 1 , 1.5 and 2 g l-1. The result showed the superiority of the spraying with 1.5 g l-1 in traits of leaf area, total chlorophyll, number of clusters, berry weight, cluster weight and yield of grapevine. Furthermore, spraying three times achieved