Background: Low back pain is a common disorder usually involves muscles, nerves and bones of the back that mainly caused by lumbar disc herniation. It is considered one of the major health system problems that has financial, physical, and occupational impact on patient and community. It frequently resulted in physical disability that may require surgery, commonly lumbar laminectomy. Aim of this study to assess knowledge and daily living activities for patients post lumbar laminectomy. Research design: A descriptive cross-sectional design. Subjects: A convenient sample consisted of 130 patients with lumbar laminectomy admitted to neurosurgical outpatient clinic of Damanhour Medical National Institute. Tools: three tools were used: tool I: Patient assessment structured interview questionnaire; tool Π: Knowledge assessment structured interview questionnaire and tool III: Barthel Index scale of activities of daily living. Results: the present study revealed that less than half of the studied patients were in the age group of 40 < 50 years, more than half of the studied patients were male and 76.9% complain of low back pain. There was positive statistically significant relation between patient's knowledge and gender and there was positive statistically significant relation between levels of dependance of activity of daily living and patient chief complain. Conclusion: majority of patients had poor level of knowledge and need assistance in daily living activities post lumbar laminectomy. Recommendations: Illustrated booklets, handouts, and audiovisual materials involving instructions regarding their needs and activities of daily living should provide to every patient in the neurosurgery department an outpatient clinic and replicating of the study using a larger sample size to ensure generalizability of results.