Background: Antenatal mental health problems are associated with maternal and fetal adverse outcomes. There are a wide range of factors associated with mental health problems during pregnancy. Aim of this study to assess risk factors of mental health problems among pregnant women in El-Beheira governorate. Research design: A descriptive cross-sectional design. Settings: This study was conducted at the governmental primary health care centers in El-Beheira governorate. Tools: Depression Anxiety Stress Scale (DASS-21) was used. Results: The prevalence of depression, anxiety and stress was 38.43%, 44.95% and 63.67% respectively. Conclusion: The prevalence of depression, anxiety and stress among studied pregnant women was high, early screening and intervention may have great significance for reducing these mental health problems and the family and society support should be brought into the intervention as well.Recommendations: Include maternal mental health problems screening and treatment as a routine part of woman, preconception, prenatal, and postpartum care.