Healthy adolescent development is a complicated and dynamic process that calls for loving and supporting communities, peers, and families. Blindness can affect adolescent`s quality of life, as a temporary or ongoing physical, mental health, intellectual, or sensory disability, Well-adjusted teenagers are those who don`t jeopardize their health and safety, feel comfortable with family members and peers, have reasonable positive self-esteem. This study designed to evaluate psychosocial and academic adjustment among visually impaired and sighted female adolescents. A descriptive comparative design was used in this study in two settings El-Noor and Amal school for the Blind female and El Sanya prep /secondary school. A purposive sample of 120 female adolescents (60 with visual impairment and 60 sighted adolescents) was selected. Two tools were used to measure the current study variables Structured Adolescents general profile questionnaire and adolescents' adjustment scale. Statistical significance differences were found between the studied VI and sighted female adolescents as regards total adjustment and it`s subscales except for personal and family adjustment. This study clearly concludes that adjustment during adolescence is an essential for both VI and sighted adolescents which was higher level among VI than sighted female adolescents. Also, visual impairment has no impact on adolescents' adjustment.  Educational programs should be done for fostering adjustment.