Objective: The aim of this review was to compare Supraclavicular Brachial Plexus Block by Ketamine-Bupivacaine versus Bupivacaine with Intravenous Ketamine Infusion Methods: A comprehensive search was conducted in search engines from August 2000 to July 2021, using the keywords . The reviewers evaluated relevant literature references as well. Only the most recent or complete study was taken into account. Results: The reviewed literature showed that VAS was significantly lower at 12 h in group 1 but insignificantly different at 1/2, 1, 1.5, 2, 3, 4, 6 and 24 h between both groups; so do postoperative heart rate and mean arterial pressure. Onset of sensory block and onset of motor block was significantly lower in group 1. Duration of sensory block and duration of motor block was significantly higher in group1. Both time of 1st rescue analgesia was significantly delayed in group 1 and total ketorolac requirements were significantly lower in group 1. Sedation score was significantly different between both groups. On the opposite postoperative respiratory rate and SpO2 were insignificantly different between both groups. Conclusion: Using ketamine bupivacaine in supraclavicular brachial plexus block in upper limb surgeries is effective in enhancing onset of the brachial plexus block and prolonging the duration of the brachial plexus block with no hemodynamic changes, it effectively prolongs postoperative analgesia and lowers the analgesic requirements compared to intravenous ketamine infusion.