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345631

Novel Chitosan Nanoparticles based 1,2,3-triazole moieties as potent drugs against multi-drug resistant bacteria

Article

Last updated: 05 Jan 2025

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Subjects

-

Tags

Chemistry and Biochemistry

Abstract

Drug resistance is a major global problem leading to higher morbidity and mortality rates especially among hospitalized patients. Hence in the present study, 1,2,3-Triazole-acetophnone molecular conjugates 3a-c were resynthesized and then used in nanoformulated composites (3a-cCNPs) using chitosan as a matrix to give nano compounds of particle size ranging from 20 to 40 nm. Antimicrobial activity of the synthesized compounds and the nanoformulated analogues against multi-drug resistant microbes revealed that 3bCNPs was the most potent candidate due to its high efficiency against multi-drug resistant (MDR) microbes that reached complete microbial cells eradication after 4 hours. The synthesized nanoparticles were fully char-acterized through TEM, FTIR and XRD which proved the homogeneity of the synthesized nanoformula with particle size ranged between 20 to 40 nm. The present findings discovered novel antimicrobial activities that may have therapeutic potentials. This discovery may lead to an assumption that the tested compounds can be used as candidates in biomedical applications against drug resistant microbes.

DOI

10.21608/ajst.2024.257728.1024

Keywords

Chitosan-1,2,3-Triazoles Nanoformulae, MDR bacteria, Characterization

Authors

First Name

Heba

Last Name

Mohamed

MiddleName

-

Affiliation

Chemistry department, Faculty of Science, Alexandria University

Email

mohamed_pg@alexu.edu.eg

City

-

Orcid

-

First Name

Bassma

Last Name

Elwakil

MiddleName

-

Affiliation

Pharos University in Alexandria

Email

bassma.hassan@pua.edu.eg

City

Alexandria

Orcid

0000-0001-6596-3156

First Name

Mohamed

Last Name

Hagar

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21568, Egypt

Email

mohamed.hajr1979@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Aouad

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 30002, Saudi Arabia

Email

aouadmohamedreda@yahoo.fr

City

-

Orcid

-

First Name

Nadjet

Last Name

Rezki

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Taibah University, Al-Madinah Al-Munawarah 30002, Saudi Arabia

Email

nadjetrezki@yahoo.fr

City

-

Orcid

-

First Name

Zakia

Last Name

Olama

MiddleName

-

Affiliation

Department of Botany & Microbiology, Faculty of Science, Alexandria University, Alexandria 21568, Egypt

Email

zakiaolama52@gmail.com

City

-

Orcid

-

First Name

Yeldez

Last Name

El Kilany

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21568, Egypt

Email

yeldez244@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Zakaria

MiddleName

-

Affiliation

Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21568, Egypt

Email

mohamed.zakaria@alexu.edu.eg

City

-

Orcid

-

Volume

2

Article Issue

1

Related Issue

48980

Issue Date

2024-06-01

Receive Date

2023-12-24

Publish Date

2024-06-01

Page Start

28

Page End

33

Print ISSN

2974-3265

Online ISSN

2974-3273

Article File

AJST_Volume 2_Issue 1_Pages 28-33.pdf

PDF . 2.1MB

Link

https://ajst.journals.ekb.eg/article_345631.html

Detail API

https://ajst.journals.ekb.eg/service?article_code=345631

Order

345,631

Type

Original Article

Type Code

2,581

Publication Type

Journal

Publication Title

Alexandria Journal of Science and Technology

Publication Link

https://ajst.journals.ekb.eg/

MainTitle

Novel Chitosan Nanoparticles based 1,2,3-triazole moieties as potent drugs against multi-drug resistant bacteria

Details

Type

Article

Created At

29 Dec 2024