Background: Entrepreneurial intention is seen as human inclinations that could result in the establishment of businesses. Aim: To assess entrepreneurial intention levels among head nurses. Study design: Descriptive correlational research design was used. Setting: The study was conducted at Sohag and Main Assiut Universities Hospitals. Subjects: 120 head nurses at two study settings 60 for each .Tools: One tool were used to collect data:  Self-administered questionnaire sheet including two parts:-a): Personal data sheet and b): Entrepreneurial Intention assessment scale. Results: The study revealed that about half of studied head nurses had moderate entrepreneurial intention level at Sohag University Hospital and Main Assuit University Hospital (48.30% and 55 %) respectively. Conclusion: At Sohag University Hospital and Main Assuit University Hospital the highest mean scores are "I have seriously though in starting a firm" in entreprenerial intention items. There was statistical significant relation between studied head nurses entrepreneurial intention and their marital status and years of experience in nursing profession at Sohag University Hospital. Recommendations: Provide workshops to foster nursing entrepreneurship awareness and provide continuous support for nurse entrepreneurs in hospitals.