Background: Academic nursing student experience problems related to anger and low self-esteem that negatively influence their academic and social development and have lasting effects on their well-being. Aim: To evaluate the effectiveness of a mindfulness program on anxiety, anger, and self-esteem among academic nursing students. Design: A quasi-experimental pre-posttest non-equivalent group design were used. Setting: The study was carried out in the Faculty of Nursing at Sohag University. Subjects: The subjects comprised of 120 academic nursing students from the first academic year was selected by purposive sampling technique involved in the study from the previously selected settings. The sample was partitioned into two groups, a study group and a control group (n = 60 academic nursing students in each group). Data collection tools: The student's personal data questionnaire, the Anxiety inventory, the Adolescent Anger Rating Scale (AARS), and the Self-esteem scale were used. Results: the level of anxiety, anger in the study group decreased in the post-test with and there were a significant difference in the posttest anxiety, anger scores between the control and study groups. The percentage of a high level of self-esteem increased in the mindfulness- program. also., there were a significant difference between the post- mindfulness- program self-esteem between the control and study groups. There were positive relationships between self-esteem, anger, and anxiety among academic nursing students.  Conclusion: The study concluded that the mindfulness- program was efficacy in reducing anxiety, and anger and improving self-esteem among academic nursing students. Recommendations: the study should replicate in order to increase confidence in the intervention's efficacy, guarantee generalizability, and improve students' mental health.