Background: Urinary tract infections are an ailment characterized by kidney inflammation that is primarily caused by bacterial infection. Purpose: To investigate the effect of implementing clinical pathways on maternity nurses' performance and birth outcomes among pregnant women with urinary tract infections. Research design: A quasi-experimental investigation was employed. Setting: The investigation was conducted at the outpatient facility situated within the University and Teaching Hospitals, Shebin EL-Kom, Menoufia University. Sample: The convenience sample encompassed all nurses within the obstetric departments and a purposive sample of 100 pregnant mothers was chosen. Tools: An interviewing questionnaire for the pregnant mothers, an assessment tool for the maternity nurses, and an observation checklist for birth outcomes. Results: After the clinical pathway application, 75% of the maternity nurses possessed commendable levels of knowledge and performance. Additionally, a noteworthy improvement was observed in the maternal and neonatal outcomes in relation to the duration of the initial phase of labor, the duration of the subsequent phase of labor, and the average APGAR score was 9.76±0.83 for the study group and 9.72±0.79 for the control group. Conclusion: The maternity nurses who participate in clinical pathways about urinary tract infection exhibit higher knowledge and performance scores after the implementation of clinical pathways. Furthermore, the pregnant women with urinary tract infections who underwent the clinical pathway exhibit a better maternal and neonatal outcome. Recommendation: Enhance the caliber of healthcare dispensed at the grassroots level via periodic evaluation of pregnant mothers with urinary tract infections.