Background: Workaholism, which is an intense drive to work that can result in decreased levels of job satisfaction and may influence the quality of nursing care.  Aim of the study: The study aimed to assess the relation between work involvement and the quality of nursing care among staff nurses. Design: A descriptive correlational design was utilized. Setting: The study was conducted in all inpatient units at Sohag University Hospitals. Subjects: A simple random sample of 274 out of 860 staff nurses. Tools: Two tools were used for data collection; (I) Nurses' work involvement questionnaire, and (II) Quality of nursing care questionnaire. Results: more than two-thirds (70.1%) of staff nurses had a high level of work involvement and less than half (44.5%) of staff nurses reported a moderate level of quality of nursing care. Conclusion: there was a highly statistically significant negative correlation between total work involvement and quality of nursing care among staff nurses. Recommendations: conducting training programs to raise staff nurses' awareness regarding of work involvement. Also, developing standards for nursing care procedures to help staff nurses provide high-quality nursing care.