Background: Cotton dust induced respiratory disorders such as cough, wheezing, shortness of breath, chest tightness, Aim: The aims of this study are assessed respiratory problems among Sohag cotton textile workers and evaluate various safety measures used during working day to stop the hazards.  Research design: descriptive cross-sectional research design was used. Setting: This study was carried out in Sohag Spinning Factory. Sample: The study sample was 550 workers. Study tools: The self-administered question was including three parts, 1) personal data sheet, 2) to evaluate factory risks and their safety measures. 3) Included the knowledge from the health register of the worker in Health Insurance included replacement checkup and interval medical examination. Results: Our research proved. The workers in the blending and picking department, carding and spinning department and combing and twisting department suffer from cough (68.3%, 60.2% and 73.7% respectively), chest pain (68.3%, 57.6%, and 64.9% respectively), and dyspnea (70.7%, 68.1% and 71.9% respectively) The difference from other departments was statically significant. Only 63.8% of workers were performed periodic medical examination. Conclusion this research involve that respiratory problems were the most important group of occupational problems in spinning factories as a result of inhalation of cotton fibers Recommendations. The study recommends with interval medical checkup should be performed to all workers in the factory. Training and health education programs should be available to all workers.