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387257

Latent Gaussian Approach to Joint Modelling of Longitudinal and Mixture Cure Outcomes

Article

Last updated: 05 Jan 2025

Subjects

-

Tags

Applied Statistics and Econometrics

Abstract

Joint modelling has become pervasive in analysing data from survival and longitudinal studies. There are several technqiues on joint analyses of datasets from both studies simultaneously. Our interest here is on approximate Bayesian inference using latent Gaussian models (LGMs) to analyse longitudinal and mixture cure outcomes with shared random effect. Longitudinal outcome was modelled using spline function to account for nonlinearity in longitudinal trajectories often seen in real life datasets, while survival outcome was modelled using Cox proportional hazards and logistic link function for latency and incidence components respectively, to account for the possibility of cure proportion. The LGMs require three levels of hierachy involving joint likelihoods of paramters and hyperparameters, defining a multivariate normal distribution for a latent field and finally priors for the hyperparamters. Posterior estimates were evaluated using Integrated Laplace approximation. Simulation study compared linear, quadratic and spline specifications for longitudinal trajectories and showed similar results for quadratic and spline function in small sample sizes and linear specification good only in large sample size. The approach was applied to renal transplantation data which comprised glomerular filtration rate of kidneys and survival event of time to graft failure. The contribution of this paper is that it adds to the literature on approximate Bayesian alternative to jointly modelling nonlinear trajectories of longitudinal outcomes and survival outcome with possibility of cure proportions and showed its computational merit over sample-based Bayesian approach.

DOI

10.21608/cjmss.2024.303748.1061

Keywords

Survival analysis, joint modelling, latent Gaussian models, shared random effect, nonlinear trajectory

Authors

First Name

Aniefiok

Last Name

Ekong

MiddleName

Henry

Affiliation

Department of Statistics, College of Physical Sciences, Federal University of Agriculture Abeokuta, Ogun state, Nigeria.

Email

anieekong@outlook.com

City

-

Orcid

0000-0003-0621-5224

First Name

Matthew

Last Name

Olayiwola

MiddleName

Olaniyi

Affiliation

Department of Statistics, Federal University of Agriculture Abeokuta, P.M.B 2240, Abeokuta, Ogun State, Nigeria

Email

olayiwolaom@funaab.edu.ng

City

-

Orcid

-

First Name

Abayomi

Last Name

Dawodu

MiddleName

Ganiyu

Affiliation

Department of Statistics, Federal University of Agriculture Abeokuta, P.M.B 2240, Abeokuta, Ogun State, Nigeria

Email

dawoduga@funaab.edu.ng

City

-

Orcid

-

First Name

Ademola

Last Name

Osinuga

MiddleName

Idowu

Affiliation

Department of Mathematics, Federal University of Agriculture Abeokuta, P.M.B 2240, Abeokuta, Ogun State, Nigeria

Email

osinugaia@funaab.edu.ng

City

-

Orcid

-

Volume

4

Article Issue

1

Related Issue

50936

Issue Date

2025-04-01

Receive Date

2024-07-12

Publish Date

2025-04-01

Page Start

72

Page End

95

Print ISSN

2974-3435

Online ISSN

2974-3443

Link

https://cjmss.journals.ekb.eg/article_387257.html

Detail API

https://cjmss.journals.ekb.eg/service?article_code=387257

Order

387,257

Type

Original Article

Type Code

2,545

Publication Type

Journal

Publication Title

Computational Journal of Mathematical and Statistical Sciences

Publication Link

https://cjmss.journals.ekb.eg/

MainTitle

Latent Gaussian Approach to Joint Modelling of Longitudinal and Mixture Cure Outcomes

Details

Type

Article

Created At

29 Dec 2024