Background: Human coronaviruses are one of the principle causes of upper respiratory infections, which were defined for the first time in 1962. A systemic inflammation that includes cytokine storm and thrombosis formation is the underlying cause of severe cases of COVID-19 patients that lead to multi-organ dysfunction.Aim: To assess the beneficial effect of corticosteroids and anticoagulants in treatment of COVID-19 in diabetic and hypertensive patients who were associated with other co-morbidities of chronic diseases or not, in addition to determination of the role of the anti-inflammatory markers in the prognosis of the disease and their correlation with CT imaging. Patients and methods: The study was conducted in the chest Department, Kobry El Kobba Military Hospital on 110 patients who were diagnosed with moderate and severe COVID-19.
Results: Treatment with corticosteroids and anticoagulants decreased significantly the duration of hospital admission, need for oxygen in the survived treated patients compared to non-survived patients in addition to decline in the inflammatory markers (CRP, IL-6, D-dimer) especially Il6 which was the most prognostic test in all groups regardless the associated morbidity. This was correlated with CT imaging scoring. Conclusion: The early administration of corticosteroids and anticoagulants to severe COVID-19 pneumonic cases reduced the negative impacts in all group of patients regardless the associated morbidity or chronic diseases. Mortality was mainly increased in patients with older age, co-morbidity, worse CT findings, a higher oxygen therapy requirement, and a longer duration of hospitalization. IL-6 level after treatment has the best prognostic accuracy, followed by D-dimer level.
Key Words: Corticosteroids, Anticoagulants, COVID 19. 
Background: Human coronaviruses are one of the principle causes of upper respiratory infections, which were defined for the first time in 1962. A systemic inflammation that includes cytokine storm and thrombosis formation is the underlying cause of severe cases of COVID-19 patients that lead to multi-organ dysfunction.Aim: To assess the beneficial effect of corticosteroids and anticoagulants in treatment of COVID-19 in diabetic and hypertensive patients who were associated with other co-morbidities of chronic diseases or not, in addition to determination of the role of the anti-inflammatory markers in the prognosis of the disease and their correlation with CT imaging. Patients and methods: The study was conducted in the chest Department, Kobry El Kobba Military Hospital on 110 patients who were diagnosed with moderate and severe COVID-19.
Results: Treatment with corticosteroids and anticoagulants decreased significantly the duration of hospital admission, need for oxygen in the survived treated patients compared to non-survived patients in addition to decline in the inflammatory markers (CRP, IL-6, D-dimer) especially Il6 which was the most prognostic test in all groups regardless the associated morbidity. This was correlated with CT imaging scoring. Conclusion: The early administration of corticosteroids and anticoagulants to severe COVID-19 pneumonic cases reduced the negative impacts in all group of patients regardless the associated morbidity or chronic diseases. Mortality was mainly increased in patients with older age, co-morbidity, worse CT findings, a higher oxygen therapy requirement, and a longer duration of hospitalization. IL-6 level after treatment has the best prognostic accuracy, followed by D-dimer level.